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KMID : 0903520080510020102
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2008 Volume.51 No. 2 p.102 ~ p.107
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The Antihypertensive and Vasodilating Effects of Adventitious Root Extracts of Wild Ginseng
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Hong Min-Hee
Lee Young-Jae
Kim So-Mi
Cho Moon-Jae
Lim Hee-Kyoung
Park Ji-Eun
Jun Neung-Jae
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Abstract
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Nitric oxide (NO) is a potent antihypertensive and vasodilator which plays an important role in regulating vascular tones. In this study, we investigated the effects of adventitious root extracts of wild ginseng on NO production and NO linked physiological activities. When human endothelial cell line (ECV304) was incubated with either water extracts of wild ginseng adventitious root (WE) or aqueous fraction of butanol extracts of wild ginseng adventitious root (ABE), considerable amounts of NO were released by the cells. The level of endothelial nitric oxide synthase (eNOS) expression was unchanged and about 6% of the angiotensin converting enzyme (ACE) was inhibited with treatment of ABE. The vasodilating activities of pulmonary artery rings in response to different doses of extracts were shown as 44.8% and 91.3% in 2.5 mg/ml WE and 0.1 mg/ml ABE, respectively. The blood pressure lowering effect was observed from the oral administered spontaneously hypertensive rat (SHR) with the lowest blood pressure (154.5±8.6 mmHg) after 8 h. The blood pressure was recovered to the initial level after 24 h.
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KEYWORD
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hypertension, nitric oxide (NO), nitric oxide synthase (NOS), vasodilation, wild ginseng adventitious root
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